1,3-Dipolar cycloadditions. XXXIII. Differences in the reactivity of substituted nitrilimines was written by Huisgen, Rolf;Adelsberger, Klaus;Aufderhaar, Ernst;Knupfer, Hans;Wallbillich, Guenter. And the article was included in Monatshefte fuer Chemie in 1967.Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:
cf. CA 67: 99380s. Disubstituted nitrilimines (16), released from hydrazide halides with Et3N were compared in their ability to undergo cycloadditions with 12 dipolarophiles of various activities. Electron-attracting substituents on the nitrilimine C and N stabilized the ground state, reduced the 1,3-dipolar activity, and promoted the formation of tetrasubstituted 1,4-dihydro-1,2,4,5-tetrazines (I). At least 3 different reaction paths from hydrazide halides to 1,4-dihydrotetrazines were shown. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).
Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics