1128-54-7, A common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 100 ml round bottom flask was added 3-methyl-1-phenyl -1H- pyrazole (1.58 g, 0.010 mol), was added 50 ml of carbon tetrachloride was added N- bromosuccinimide at room temperature (2.20 g, 0.012 mol), was added a catalytic amount of azobisisobutyronitrile (of AIBN), the reaction was warmed to reflux and maintained under reflux conditions for 2 hours. After the reaction was stopped, cooled to room temperature, filtered to remove the solid in the system, the filtrate was concentrated by column chromatography (eluent: ethyl acetate: petroleum ether = 1: 100) to obtain 1.60 g of 1-phenyl-3-bromo methyl -1H- pyrazole as a white solid in 70% yield.
The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.