Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (cas: 378203-86-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Formula: C7H9N3O4
Solid-phase Parallel Synthesis of 4-β-D-Ribofuranosylpyrazolo[4,3-d]pyrimidine Nucleosides was written by Ramasamy, Kanda S.;Amador, Roberto B.;Habib, Qazi;Rong, Frank;Han, Xiaogang;Li, David Y.;Huang, Jingfan;Hong, Zhi;An, Haoyun. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2005.Formula: C7H9N3O4 The following contents are mentioned in the article:
The synthesis of pyrazolo[4,3-d]pyrimidine nucleoside library using resin solid-phase parallel synthesis methodol. in the presence of 2,6-lutidine is described. Glycosylation of the trimethylsilyl (TMS) derivative of 1- and 2-(methyl)-1H and 2H-pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)-dione with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose in the presence of TMS triflate provided two novel protected nucleosides. Different amines were introduced selectively by nucleophilic substitution using solid-phase parallel semi-automated synthesizer. Cleavage of the products from the solid support with 30% hexafluoro isopropanol (HFIP) in a parallel fashion yielded nucleoside libraries simultaneously, and they were analyzed and characterized by high-throughput LC-MS. This study involved multiple reactions and reactants, such as Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (cas: 378203-86-2Formula: C7H9N3O4).
Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (cas: 378203-86-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Formula: C7H9N3O4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics