Palladium-Catalyzed Chelation-Assisted Regioselective Oxidative Dehydrogenative Homocoupling/Ortho-Hydroxylation in N-Phenylpyrazoles was written by Batchu, Harikrishna;Bhattacharyya, Soumya;Kant, Ruchir;Batra, Sanjay. And the article was included in Journal of Organic Chemistry in 2015.HPLC of Formula: 17355-75-8 The following contents are mentioned in the article:
A palladium-catalyzed pyrazole-directed regioselective oxidative C(sp2)-H functionalization of the N-Ph ring in N-phenylpyrazoles to afford either a biaryl bis-pyrazole I [R1 = H, Me, Ph, and CO2Et; R2 = H, CO2Et; R3 = H, Me, Pr, etc.; R = H, Me, Cl, etc.] (via dehydrogenative homocoupling) or N-(o-hydroxyphenyl)pyrazole II [R1 = H, Me, Ph, and CO2Et; R2 = H, CO2Et; R3 = H, Me, Pr, etc.; R = H, Me, Cl, etc.] (via C-H oxygenation) or their mixture is described. The substitutions on the N-Ph ring and the pyrazole ring and the dilution of the reaction medium with respect to the TFA/TFAA mixture (substrate concentration) have a remarkable influence on the outcome of the reaction. It was discovered that if the reactions were performed under highly dilute conditions (ca. 10 times) then N-(o-hydroxyphenyl)pyrazoles were the major or the sole products. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8HPLC of Formula: 17355-75-8).
Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. HPLC of Formula: 17355-75-8
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics