Mugnaini, Claudia published the artcileSynthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease, HPLC of Formula: 637336-53-9, the main research area is adamantanylcarboxamidothiophene preparation cannabinoid 2 receptor agonist skin inflammation; CB2R agonists; CBR ligands; Chemokine release; Skin inflammation.
A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist Me 2-[((adamantan-1-yl)carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate , showing the best balance between receptor affinity and selectivity, was tested in vitro in an exptl. model of allergic contact dermatitis and is able to block the release of MCP-2 in HaCaT cells at 10 μM concentration
European Journal of Medicinal Chemistry published new progress about Allergic contact dermatitis. 637336-53-9 belongs to class pyrazoles-derivatives, name is Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, and the molecular formula is C6H9N3O2, HPLC of Formula: 637336-53-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics