Schreiner, Ella published the artcileConsecutive Three-Component Synthesis of 2,6-Disubstituted Pyrimid-4(3H)-ones and 1,5-Disubstituted 3-Hydroxypyrazoles Initiated by Copper(I)-Catalyzed Carboxylation of Terminal Alkynes, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrimidone hydroxypyrazole preparation green chem; terminal alkyne carboxylation copper catalyst methylation Michael addition cyclocondensation.
A copper(I)-catalyzed carboxylation of terminal alkynes followed trapping of the carboxylate with Me iodide provides a straightforward access to 3-substituted Me propiolates that can be reacted in the same reaction vessel in a consecutive fashion to give 2,6-disubstituted pyrimid-4(3H)-ones I (R1 = Ph, 4-MeOC6H4, 4-MeC6H4, etc.; R2 = Me, Ph, 4-H2NC6H4, etc.) and 1,5-disubstituted 3-hydroxypyrazoles II (R1 = Ph, 4-MeOC6H4, etc.; R2 = H, Me, Bn, etc.) in moderate to good yields. The Cu(I)-catalyzed carboxylation with carbon dioxide as C1 source therefore provides an environmentally benign entry to three-carbon building blocks in heterocyclic synthesis.
Advanced Synthesis & Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics