Kottha, Thirumalaswamy S.’s team published research in ChemistrySelect in 2018 | CAS: 27412-71-1

ChemistrySelect published new progress about Gastrointestinal absorption. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Kottha, Thirumalaswamy S. published the artcileA Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4-Aryl-4H-Chromenes and in silico Tubulin Inhibitor Studies, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is aryl chromene bioisosteric analog preparation green chem tubulin inhibitor.

An eco-friendly reaction protocol was developed for the synthesis of heterocyclic hybrid scaffolds through bioisosteric replacement and scaffold hopping approach. The isosteric analogs of salicylaldehyde were designed, identified/synthesized and employed in a three component reaction to afford bioisosteric analogs of 4-aryl-4H-chromenes. Thus central core swapping of benzene-pyridine/pyrazole ring on 4-aryl-4H-chromenes was achieved under simple one-pot reaction conditions and easy work-up. Docking studies show that almost all the compounds possess good binding affinities at the colchicine binding site of tubulin.

ChemistrySelect published new progress about Gastrointestinal absorption. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics