Kamal, Raj; Kumar, Vipan; Kumar, Ravinder; Bhardwaj, Jitender K.; Saraf, Priyanka; Kumari, Priya; Bhardwaj, Vikas published an article in 2017, the title of the article was Design, Synthesis, and Screening of Triazolopyrimidine-Pyrazole Hybrids as Potent Apoptotic Inducers.HPLC of Formula: 36640-53-6 And the article contains the following content:
An efficient synthesis of novel 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-5,7-dimethyl-[1,2,4]triazolo[4,3-a]-pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in the testicular germ cells of goat (Capra hircus). This study aimed at assessing the cytol. and biochem. changes in testicular germ cells after the exposure to triazolopyrimidines in a dose- and time-dependent manner. Histomorphol. anal., fluorescence assays, apoptosis quantification, and terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling (TUNEL) assays were performed to determine cytol. changes, whereas thiobarbituric acid-reactive substance (TBARS) and ferric reducing antioxidant power (FRAP) assays were carried out to measure the oxidative stress in triazolopyrimidines treated germ cells. The parallel use of these methods enabled us to determine the role of triazolopyrimidines in inducing apoptosis as a consequence of cytogenetic damage and oxidative stress generated in testicular germ cells of goat. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).HPLC of Formula: 36640-53-6
The Article related to screening triazolopyrimidine pyrazole apoptosis inducer, cytotoxic activity, pyrazole, synthesis, triazole, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 36640-53-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics