Cotesta, Simona et al. published their patent in 2021 |CAS: 2089292-88-4

The Article related to pyrazolyl derivative preparation anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C7H6BrN3

On June 24, 2021, Cotesta, Simona; Gerspacher, Marc; Leblanc, Catherine; Liu, Bo; Lorthiois, Edwige Liliane Jeanne; Machauer, Rainier; Mah, Robert; Mura, Christophe; Rigollier, Pascal; Schneider, Nadine; Stutz, Stefan; Vaupel, Andrea; Warin, Nicolas; Wilcken, Rainer published a patent.Formula: C7H6BrN3 The title of the patent was Pyrazolyl derivatives useful as anti-cancer agents. And the patent contained the following:

Pyrazolyl derivatives of formula I [A = cycloalkyl, heterocyclyl, aryl, heteroaryl, etc.; B = aryl, heteroaryl, etc.; C = H, alkyl, cycloalkyl, fluoroalkyl, CN, CH2OH, etc.; L = spirocycloalkyl, etc.; G = COCH=CH2, COCCH, SO2-alkylene, etc.] or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, are prepared as anticancer agents. Thus, (R)-II was prepared, and had IC50 value of 0.017μM in KRASG12C covalent competition assay. The experimental process involved the reaction of 5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine(cas: 2089292-88-4).Formula: C7H6BrN3

The Article related to pyrazolyl derivative preparation anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C7H6BrN3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics