On May 24, 2018, Gavrilov, Aleksey Sergeevich; Aleshunin, Pavel Aleksandrovich; Gorbunova, Svetlana Leonidovna; Rekharsky, Mikhail Vladimirovich; Kozhemyakina, Natalia Vladimirovna; Kukushkina, Anna Aleksandrovna; Kushakova, Anna Sergeevna; Mikhaylov, Leonid Evgen’evich; Moldavsky, Alexander; Popkova, Aleksandra Vladimirovna; Silonov, Sergey Aleksandrovich; Smirnova, Svetlana Sergeevna; Iakovlev, Pavel Andreevich published a patent.Synthetic Route of 924909-16-0 The title of the patent was Pyrazolopyridine and indazole derivatives as inhibitors of Bruton’s tyrosine kinase and their preparation. And the patent contained the following:
The invention relates to a compound of formula I or pharmaceutically acceptable salt, solvate or stereoisomer thereof, which have properties of inhibitor of Bruton’s tyrosine kinase (Btk), to pharmaceutical compositions containing such compounds, and their use as pharmaceuticals for treatment of diseases and disorder. Compounds of formula I wherein V1 is C and N; V2 is CR2 and N; M is absent and CH2; K is absent and LR3; L is CH2, NH, O and a bond; R1 is (un)substituted 4-(4-oxo-4H-pyridin-1-yl)aryl, (un)substituted 4-(aryloxy)aryl, (un)substituted 4-(arylaminocarbonyl)aryl, etc.; R2 and R11 are independently H, D,halo, CN, C1-6 alkoxy, etc.; R3 is H, halo, CN, OH, C1-6 alkyl, etc.; R6 is N-substituted azetidin-3-yl, N-substituted pyrrolidinyl, and N-substituted piperidin-3-yl; and pharmaceutically acceptable salts, solvates, and stereoisomers thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their BTK inhibitory activity (data given). The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).Synthetic Route of 924909-16-0
The Article related to pyrazolopyridine indazole preparation bth inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 924909-16-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics