On September 7, 2021, Cho, Won Je published a patent.Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the patent was Preparation of pyrazolecarboxamide for preventing or treating metabolic disease. And the patent contained the following:
The present invention relates to a novel pyrazolecarboxamide carboxamide compound I [R1 = H, 3-OMe, 3,4-(OMe)2, 4-Me; R2 = H, CF3, NH2; OR3 = meta-(3-pyridinyloxy), para-(4-isopropylphenyl), para-(2-methoxy-4-methylphenyl), etc.] and a composition for preventing or treating metabolic diseases, wherein the composition is a potent and selective estrogen-related receptor (ERR) γ inverse agonist with excellent selectivity and since it shows affinity, it can be effectively used for treatment of metabolic diseases. For example, II was prepared and exhibited IC50 of 1.33μM against estrogen-related receptor (ERR) γ. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde
The Article related to preparation pyrazolecarboxamide treatment metabolic disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics