On February 4, 2020, Wang, Renxiao; Liu, Hong; Yu, Biao; Li, Yangfeng; Li, Chunpiao; Li, Yan; Zhou, Mi; Li, Qing; Su, Minyi published a patent.Application of 36640-53-6 The title of the patent was Phenyl pyrazole compound, its pharmaceutical composition, preparing method and application. And the patent contained the following:
The invention relates to Ph pyrazole compounds of formula I and II, their preparation and application as Bcl inhibitor. Compounds I and II, wherein Ra is R1(O)n(CH2)m; R1 is C6-14 aryl or substituted C6-14 aryl; m is 0-6; n is 0 or 1; R is H or C1-C4 alkyl; Rb and Rc are independently H, C3-C8 cycloalkyl, C1-C6 alkyl, etc.; their stereoisomers, or pharmaceutically acceptable salts, are claimed. The inventive compound can be applied in preparing the drugs for preventing and/or treating Bcl-related diseases or preparing Bcl inhibitor, with high activity and low toxicity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Application of 36640-53-6
The Article related to phenyl pyrazole preparation bcl inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 36640-53-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics