On November 17, 2011, Mulvihill, Mark J.; Steinig, Arno G.; Crew, Andrew Philip; Jin, Meizhong; Kleinberg, Andrew; Li, An-Hu; Wang, Jing published a patent.Category: pyrazoles-derivatives The title of the patent was Preparation of fused bicyclic heterocycles as kinase inhibitors. And the patent contained the following:
Title compounds I [X = H, (C1-3)alkyl, O(C1-3)alkyl, either is optionally substituted with halo or CN; W-V = C-N or N-C; Y1, Y2 = N or CH as long as not more than one of Y1 and Y2 is N; Y3 = NH, CH; Y4 = N, CH; Y5 = N, C as long as not more than one of Y4 and Y5 is N; R3 , R4, R5, R6, R7 = H, alkyl, cyclic compound, O-alkyl, O-cyclic compound, S, SO2, SO, NH2, CONH2, CO2H, acyl, ureido, S-cyclic compound; G1 = H, alkyl, cyclic compound; R17, R18 = H, alkyl, O-alkyl, CONH2, cyclic compound, CO2H, NH2] were prepared and tested in different kinase inhibitory assays. For example, reacting (4-bromo-1-methyl-1H-pyrazol-3-yl)methanol with borane II gave pyrrolo[2,3-b]pyridine III. The compounds are also useful for treating cancers in part by inhibiting different kinases such as MET, RON, or ALK. This abstract is not limiting of the invention. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Category: pyrazoles-derivatives
The Article related to bicyclic heterocycle fused preparation anticancer kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics