35344-95-7, Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7.
To a stirred solution of 1H-pyrazole-4-carbaldehyde (1.00 g. 10.4 mmoi) and6-bromo-4-rnethyinicotinonitrile (2.05 g, 10.4 mrnol) in dioxane (15 mL) were added K2C03 (4.31 g, 31.2 mrnol) The resulting reaction mixture was degassed with nitrogen for 5 minutes and was added copper(1) iodide (0595 g, 3. 12 mmoi), followed by trans_N,NLdimethylcyciohexanei .2-diamine (2.59 mL, 16.4 mmoi). The resulting reaction mixture was degassed with nitrogen for an additional 5 minutes and heated at110 ¡ãC for 1 h under microwave irradiation. The reaction mixture was cooled to ambient temperature, filtered through celite and the organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-24 g, 20-40percent EtOAc/ n-hexane) to obtain Intermediate 9 (115 g, 52.1percent) as a pale yellow solid. ?H NMR (300 MHz, DMSO?d6) oe ppm 2.62 (s, 3 H), 8.10 (s, I Fl), 8.38 (s, I H), 8.95 (s, IH), 9.37 (s, I H), 998 (s, I H). LCMS (method-i)), retention time 1.68 mi [M+Hi213.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.