On November 26, 2020, Bandiera, Tiziano; Bertozzi, Fabio; Di Fruscia, Paolo; Sorana, Federico; Berti, Francesco; Rodriguez Gimeno, Alejandra; Caci, Emanuela; Ferrera, Loretta; Pedemonte, Nicoletta; Vicente Galietta, Luis Juan published a patent.Synthetic Route of 1186608-73-0 The title of the patent was Preparation of pyrazolopyridines and related heterocycles and compositions containing them for the treatment of cystic fibrosis. And the patent contained the following:
The invention relates to preparation of pyrazolopyridines and related heterocycles of formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds I and their uses, in particular to modulate CFTR protein or ABC protein activities. Compounds I wherein R1 is H; Z is CO or SO2; X1-X4 each independently is CRVII and N, with the proviso that the number of nitrogen atoms in the ring is comprised from O to 2; R2 is H, OH, NO, etc.; A1-A4 each independently is O, SO2, CO, etc.; B represents an unsubstituted or a substituted aromatic or heteroaromatic ring; n and m are each independently selected from the group consisting of O, 1, 2; etc., are claimed. The example compound II was prepared using 3-hydrazinobenzoic acid as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I and pharmaceutical composition comprising them, are modulators of CFTR protein or ABC protein activities, and can be used in treatment of cystic fibrosis and other diseases. The experimental process involved the reaction of 3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine(cas: 1186608-73-0).Synthetic Route of 1186608-73-0
The Article related to pyrazolopyridine preparation cftr modulator abc protein cystic fibrosis treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Synthetic Route of 1186608-73-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics