On September 11, 2014, Vankayalapati, Hariprasad; Yerramreddy, Venkatakrishnareddy; Ganipisetty, Venu Babu; Talluri, Sureshkumar; Appalaneni, Rajendra P. published a patent.HPLC of Formula: 924909-16-0 The title of the patent was Preparation of substituted 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors. And the patent contained the following:
The present invention relates to compounds I-III [X = N or CH; L1 = H, F, (un)substituted Ph, etc.; Q = direct bond, thienyl, thiazolyl, Ph, etc.; R1 = H, halo, CN, etc.; Z = direct bond, thienyl, thiazolyl, Ph, etc.; R2 = H, halo, CN, etc.; n = 0-2; m = 0-2; with the provisos], to pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes. Over two-hundred compounds I were prepared and/or claimed. E.g., a multi-step synthesis of IV, starting from 2,2-dimethyl-1,3-dioxane-4,6-dione and 1-(4-methoxybenzyl)-1H-pyrazol-5-amine, was described. Exemplified compounds I were tested against SIK2 (data given for representative compounds I). The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).HPLC of Formula: 924909-16-0
The Article related to pyrrolopyridine pyrazolopyridine preparation salt inducible kinase 2 sik2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.HPLC of Formula: 924909-16-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics