Verma, Anil; Kumar, Vinod; Kataria, Ramesh; Singh, Joginder published an article in 2019, the title of the article was Novel acetohydrazide pyrazole derivatives, design, synthesis, characterization and antimicrobial activity.Computed Properties of 36640-53-6 And the article contains the following content:
Eleven acetohydrazide linked pyrazole derivatives I [R = Ph, thiophen-2-yl, 1-naphthyl, etc.] were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds I were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds I were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. I [R = 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl] were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives I as compared to other groups present in the ring. Hence, among compounds I [R = 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl] could be explored further against other microbes to prove its vitality. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Computed Properties of 36640-53-6
The Article related to diphenyl pyrazolylmethylene acetohydrazide preparation antibacterial antifungal activity sar, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 36640-53-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics