On September 30, 2012, Siddhartha, Tarun; Mithilesh; Sharma, Raju; Chawla, Pooja; Saraf, S. K. published an article.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Syntheses and antioxidant screening of pyrazole-4-carboxaldehyde derivatives. And the article contained the following:
Pyrazole-4-carboxaldehydes were synthesized by AcOH-mediated condensation of aryl Me ketones with phenylhydrazines in EtOH to afford the corresponding phenylhydrazones. Subsequent reaction with 2 equiv DMF-POCl3 adduct (Vilsmeier Haack reagent) in DMF at 60-70° for 6 h afforded immonium perchlorates. Further, alk. hydrolysis (NaOH) afforded pyrazole-4-carboxaldehydes. All the synthesized compounds were screened for antioxidant activity. In a ferric reducing power assay, increased absorbance of the compounds with concentration indicates increased reducing power. Compounds with higher concentrations showed a higher reducing power. The reducing power showed good linear relation (R2) in both standard as well as in the newly prepared compounds Thus, the compounds have antioxidant activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde
The Article related to phenylhydrazone vilsmeier haack cyclization formylation, pyrazolecarboxaldehyde preparation antioxidant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics