On December 20, 2019, Xu, Zichen; Wei, Wanguo; Fang, Xianjie; Liu, Rufeng; Yi, Mingyue; Zhou, Chenglong; Liu, Jie published a patent.Computed Properties of 1187582-58-6 The title of the patent was Preparation method of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. And the patent contained the following:
The invention relates to a process for the preparation of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. For instance, Suzuki reaction of 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzonitrile with 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole followed by deprotection, N-alkylation with N-Boc-L-alaninol, amidation with 5-acetyl-1H-pyrazole-3-carboxylic acid Et ester, and reduction to give N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide. The experimental process involved the reaction of 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole(cas: 1187582-58-6).Computed Properties of 1187582-58-6
The Article related to chlorocyanophenyl pyrazolylmethylethylhydroxyethyl pyrazolecarboxamide preparation suzuki alkylation amidation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 1187582-58-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics