On December 6, 2007, Blom, Petra; Defert, Olivier; Kaletta, Titus; Leysen, Dirk Casimir Maria published a patent.Name: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of thiazole and pyridinyl carboxamides and related heterocyclic analogs that interact with ion channels. And the patent contained the following:
Title compounds I [X = substituted thiazole, pyridine, oxopiperidine, etc.; R1 = H, halo, OH, NO2, alkyl, etc.; L1 = alkylene, cycloalkylene, pyrrolidinlenealkylene, etc.; m = 0-4], and their pharmaceutically acceptable salts, are prepared and disclosed as being capable of interacting with ion channels, in particular ion channels from the kv family. Thus, e.g., II was prepared by coupling of the corresponding 4-bromothiazole derivative (preparation given) with Ph boronic acid. Inhibition assays of the kv4.3 ion channel are described, e.g., II provided above 50% inhibition. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Name: 5-Methoxy-1H-pyrazole
The Article related to thiazole carboxamide derivative preparation ion channel modulator kv, pyridine carboxamide derivative preparation ion channel modulator kv, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: 5-Methoxy-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics