Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Quality Control of 2075-46-9.
Zhu, Shuangfei;Yang, Wei;Gan, Qiang;Cheng, Nianshou;Feng, Changgen research published 《 Comparative study on the thermal decomposition of structural isomers: Pyrazole and imidazole energetic materials》, the research content is summarized as follows. Exploration of the thermal decay mechanisms of energetic skeletons supports the understanding of stability and energy release. Herein, the thermal decomposition is comparatively investigated of energetic isomers nitropyrazole and nitroimidazoles at high temperature and high d. based on ReaxFF-lg reactive mol. dynamics simulations, which have not been fully understood. Results show that the initial decomposition reaction of nitropyrazole and nitroimidazole were triggered by the OH elimination as a result of intermol. H-shift. The N2 elimination plays a major role in the decomposition of pyrazoles, while the formation of hydrogen cyanide CHN is the main decomposition channel of imidazoles. Another important channel of their nitro derivatives is C-NO2 bond dissociation At high d., the cleavage of C-NO2 bonds is inhibited, and the reactions between mols. are promoted, therefore the dimers are easier to produce. Detailed evolution yields of key intermediates, final gaseous products, and clusters are also presented to study the difference in the thermal decay of pyrazoles and imidazoles, as well as the effect of pressure. Overall, these thermolysis properties of nitropyrazole and nitroimidazole are expected to gain more knowledge to the diversity of thermal decomposition of energetic isomers.
2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., Quality Control of 2075-46-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics