Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. HPLC of Formula: 2075-46-9.
Zhou, Hongyan;Xiang, Xiancheng;Ma, Ben;Wang, Ganggang;Zhang, Zhixia;Yang, Jingya research published 《 Lithium Chloride Catalyzed Aza-Michael Addition of Pyrazoles to α,β-Unsaturated Imides》, the research content is summarized as follows. A lithium chloride catalyzed aza-Michael reaction of pyrazoles to α,β-unsaturated imides was developed. A range of aromatic and aliphatic α,β-unsaturated imides were found to be suitable for the established method, provided the corresponding aza-Michael adducts in up to 93% yields. The inexpensive catalyst, good substrate tolerance and ease of scale-up made this procedure highly practical.
HPLC of Formula: 2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics