6126-22-3, name is 3-Amino-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 6126-22-3
Scheme 3 (FIG. 17) is one synthetic pathway for preparing 6,6?-(4-nitro-1H-pyrazole-3,5- diyl)bis(3 -bromo-7-methylpyrazolo[ 1,5 -alpyrimidin-2( 1H)-one) (compound 8). Compound 8 differs from ANY1 by introduction of two additional methyl groups. Based on the crystal structure data, the methyl groups should be readily accommodated and may increase binding affinity. Briefly, pyrazol-3-one 1 is condensed with 2 to generate bicyclic 1,2-dihydropyrazolo[1,5-alpyrimidine 3. Selective bromination of 3 can be accomplished under free radical (shown) or direct bromination conditions to furnish 4. At this stage, a portion of ester 4 will undergo saponification to generate acid 5.Next, 5 is coupled to CH3NHOCH3 to yield the corresponding Weinreb amide, which can then be transformed to the corresponding methyl ketone 6 by reaction with the Grignard reagentmethyl magnesium bromide. Ester 4 and methyl ketone 6 are then coupled to yield a 1,3- dicarbonyl compound that is condensed with hydrazine to yield the pyrazole core in compound 7. Finally, mild nitration with copper (II) nitrate will deliver compound 8, a direct analogue of ANY 1
Statistics shows that 6126-22-3 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1H-pyrazol-5(4H)-one.