Pyrazoles and pyrimidines have diverse biological and pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Quality Control of 761446-44-0.
Watson, Robert J.;Bamborough, Paul;Barnett, Heather;Chung, Chun-wa;Davis, Rob;Gordon, Laurie;Grandi, Paola;Petretich, Massimo;Phillipou, Alex;Prinjha, Rab K.;Rioja, Inmaculada;Soden, Peter;Werner, Thilo;Demont, Emmanuel H. research published 《 GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins》, the research content is summarized as follows. Pan-bromodomain and extra terminal (BET) inhibitors interact equipotently with all eight bromodomains of the BET family of proteins. They have shown profound efficacy in vitro and in vivo in oncol. and immunomodulatory models, and a number of them are currently in clin. trials where significant safety signals have been reported. It is therefore important to understand the functional contribution of each bromodomain to assess the opportunity to tease apart efficacy and toxicity. This article discloses the in vitro and cellular activity profiles of GSK789(I), a potent, cell-permeable, and highly selective inhibitor of the first bromodomains of the BET family.
Quality Control of 761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics