Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. HPLC of Formula: 2075-46-9.
Wang, Ban;Mccabe, Gavin E.;Parrish, Mitchell J.;Singh, Jujhar;Zeller, Matthias;Deng, Yongming research published 《 Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles》, the research content is summarized as follows. Disclosed herein was a photoinduced selective hydroamination of ynamides with nitrogen heteroaromatic nucleophiles. By using an organocatalytic photoredox system, a direct method to construct a diverse of (Z)-α-aryl enamides I [R1 = Ph, n-hexyl, 4-MeC6H4, etc.; R2 = Me, t-Bu, Bn; R3 = Ms, Ts, Ns; Ar = pyrazol-1-yl, triazol-1-yl, (5-methyltetrazol-2-yl), etc.] from ynamides and pyrazoles, as well as triazoles, benzotriazoles, indazoles, and tetrazoles, was developed, thus providing a photocatalytically synthetic route to heterocyclic motifs common in medicinal agents. Based on the mechanistic studies, the hydroamination was postulated to operate via a mechanism in which the single-electron oxidation of ynamide and the intermediacy of an alkyne radical cation, was responsible for the observed reactivity.
2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., HPLC of Formula: 2075-46-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics