Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. SDS of cas: 2075-46-9.
Stivanin, Mateus L.;Gallo, Rafael D. C.;Spadeto, Joao Paulo M.;Cormanich, Rodrigo A.;Jurberg, Igor D. research published 《 A visible light-mediated three-component strategy based on the ring-opening of cyclic ethers with aryldiazoacetates and nucleophiles》, the research content is summarized as follows. A blue light-promoted reaction between aryldiazoacetates 4-R1C6H4C(=N2)C(O)2R2 (R1 = F, Cl, CF3, etc.; R2 = Me, t-Bu, Bn, propargyl) and different nucleophiles, e.g., benzoic acid has been developed in the presence of THF (and other cyclic ethers like THP, 1,4-dioxane, and 1,4,7,10,13,16-hexaoxacyclooctadecane) as the solvent, allowing the incorporation of these three elements into a single products, e.g., I. Formally, this transformation represents an O-H insertion strategy of more complex alcs. into aryldiazoesters without the need of pre-assembling them. The method is mild and efficient and proceeds in the absence of metals, generally at room temperature
2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., SDS of cas: 2075-46-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics