As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5932-27-4 name is Ethyl 1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 5932-27-4
Step 2: Nitrogen protection, 1H-pyrazole-3-carboxylic acid ethyl ester (3.7 g, 26.2 mmol) dissolved in dry DMF(25 mL), 60percent NaH (1.0 g, 26.2 mmol) was added in four portions at 0 ¡ãC. After stirring for 15 min, slowly add 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-fluoropyridine (4.0 g, 20.9 mmol), warmed to 110 ¡ã C and stirred overnight.The reaction was quenched by adding an appropriate amount of water and extracted three times with dichloromethane.The combined organics were dried with MgSO4 for 2 h. Filter out MgSO4,The solvent was distilled off, and the crude product was separated by column chromatography (eluent petroleum ether (60-90 ¡ã C) / ethyl acetate, 15:1 by volume) to obtain white powder.Final (5.7 g, yield 88percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.