Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. HPLC of Formula: 761446-44-0.
Pei, Haixiang;Qin, Juliang;Wang, Fengmian;Tan, Binghe;Zhao, Zeda;Peng, Yangrui;Yu, Fangfei;Li, Ennian;Liu, Mingyao;Zhang, Rong;Liu, Bo;Du, Bing;Chen, Yihua research published 《 Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages》, the research content is summarized as follows. For discovering novel compounds that target Tumor-associated macrophages (TAM), a series of ureido tetrahydrocarbazole derivatives I (R = 5-cyclopropylaminocarbonyl, 6-(morpholine-4-carbonyl), 7-isopropylaminocarbonyl, 8-(1-methylpiperazine-4-carbonyl), etc.) was designed, synthesized and evaluated both in vitro and in vivo. Among them, compound I (R = 5-(1-methyl-1H-pyrazole-4-yl)) was found to dose-dependently repolarize TAMs from M2 to M1 both in vitro and in vivo. And more importantly, the in vivo experiments also revealed that compound I (R = 5-(1-methyl-1H-pyrazole-4-yl)) was capable of remarkably inhibiting tumor growth of the LLC mouse model. Moreover, the synergy of compound I (R = 5-(1-methyl-1H-pyrazole-4-yl)) with anti-PD-1 antibody had more superior antineoplastic effects than the exclusive use of either in vivo.
HPLC of Formula: 761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics