Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Electric Literature of 761446-44-0.
Ng, Pearly Shuyi;Foo, Klement;Sim, Sandra;Wang, Gang;Huang, Chuhui;Tan, Li Hong;Poulsen, Anders;Liu, Boping;Tee, Doris Hui Ying;Ahmad, Nur Huda Binte;Wang, Sifang;Ke, Zhiyuan;Lee, May Ann;Kwek, Zekui P.;Joy, Joma;Anantharajan, Jothi;Baburajendran, Nithya;Pendharkar, Vishal;Manoharan, Vithya;Vuddagiri, Susmitha;Sangthongpitag, Kanda;Hill, Jeffrey;Keller, Thomas H.;Hung, Alvin W. research published 《 Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors》, the research content is summarized as follows. AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based lead discovery approach, a new indazole-based AXL inhibitor was obtained. The indazole fragment hit 11, identified through a high concentration biochem. screen, was expeditiously improved to fragment 24 by screening our inhouse expanded library of fragments (ELF) collection. Subsequent fragment optimization guided by docking studies provided potent inhibitor 54 with moderate exposure levels in mice. X-ray crystal structure of analog 50 complexed with the I650M mutated kinase domain of Mer revealed the key binding interactions for the scaffold. The good potency coupled with reasonable kinase selectivity, moderate in vivo exposure levels, and availability of structural information for the series makes it a suitable starting point for further optimization efforts.
Electric Literature of 761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics