On February 14, 2008, Talley, John Jeffrey; Sprott, Kevin; Pearson, James Philip; Milne, G. Todd; Schairer, Wayne; Yang, Jing Jing; Kim, Charles; Barden, Timothy; Lundigran, Regina; Mermerian, Ara; Currie, Mark G. published a patent.Synthetic Route of 1014631-89-0 The title of the patent was Indole compounds for treating pain, inflammation and other conditions. And the patent contained the following:
The title indoles such as I [V, W, X, Y, Z, J, K, L and M = N or C; P1-P6 = N or C; Q1-Q5 = N or C; A and A1 = OH or (un)substituted alkoxy; or A and A1 taken together = O, N(OH), N(OMe); or A and A1 together with the carbon atom to which they are attached form a cyclic ketal containing a total of 4 or 5 carbon atoms which can be optionally substituted; R2 = halo, OH, NO2, etc.; R4-R17 = absent, H, halo, NO2, etc.; with the provisos] that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds I are benzyl derivatives and others are benzoyl derivatives The compounds I are substituted at least at the 3 position of the indole. General synthetic methods for the preparation of compounds I are described. E.g., a multistep synthesis of {1-[(5-chlorothien-2-yl)carbonyl]-6-fluoro-5-hydroxy-2-methyl-1H-indole-3-yl}acetic acid, starting from 3-fluoro-4-methoxyaniline, was given. Pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid(cas: 1014631-89-0).Synthetic Route of 1014631-89-0
The Article related to indole preparation analgesic antiinflammatory faah dao related disorder treatment, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 1014631-89-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics