On April 3, 2014, Eskildsen, Joergen published a patent.Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid The title of the patent was Preparation of indolylalkylamide derivatives for use as positive allosteric modulators of nicotinic acetylcholine receptor. And the patent contained the following:
Title compounds I [R1, R2, R4, and R5 independently = H, F, CN, (un)substituted alkyl, alkenyl, or alkynyl; R3 = H, CN, (un)substituted alkyl, alkenyl, or alkynyl; R6 = H or Me; Q = substituted isoxazolyl, isothiazolyl, or pyrazolyl], and their pharmaceutically acceptable salts, are prepared and disclosed as pos. allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in α7 NNR receptor PAM flux activity assays, e.g., II demonstrated an EC50 value of 2200 nM. The experimental process involved the reaction of 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid(cas: 1340372-11-3).Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid
The Article related to indolylalkylamide preparation pos allosteric modulators nicotinic acetylcholine receptor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics