On September 6, 2019, Tang, Haifeng; Boyce, Sarah; Hanson, Michael; Nie, Zhe published a patent.Name: 5-Methoxy-1H-pyrazole The title of the patent was Compounds and compositions for treating conditions associated with APJ receptor activity. And the patent contained the following:
The invention relates to substituted triazoles of formula I and pharmaceutically acceptable salts thereof (wherein R1 is (Y1)0-1Y2; Y1 is (un)substituted C1-6 alkylene; Y2 is (un)substituted C3-10 cycloalkyl, (un)substituted C6-10 aryl, (un)substituted heteroaryl, etc.; R2 is (un)substituted C6-10 aryl, (un)substituted heteroaryl; R3 is (Y3)0-1Y4; Y3 is (un)substituted C1-6 alkylene; Y4 is (un)substituted C3-6 cycloalkyl, (un)substituted C6-10 aryl, (un)substituted 5- to 10-membered heteroaryl; R4 is H and C1-3 alkyl;) as apelin receptor modulators; their preparation and use in the treatment of pulmonary arterial hypertension. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their APJ modulatory activities. From the assay, it was determined that compound II exhibited EC50 value of less than 1 nM. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Name: 5-Methoxy-1H-pyrazole
The Article related to triazole preparation apj receptor modulator treatment pulmonary arterial hypertension, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 5-Methoxy-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics