On September 26, 2019, Xie, Yinong; Babiss, Lee E. published a patent.Category: pyrazoles-derivatives The title of the patent was Preparation of SHP2 inhibitors and uses thereof. And the patent contained the following:
The invention relates to compounds of formula I and their preparation, useful as inhibitors of protein tyrosine phosphatase SHP2 in the treatment of diseases such as cancer. Compounds of formula I are claimed, in which ring A is (un)substituted aryl, heteroaryl, and bicyclic ring system; X is S, O, NRa, CHRa, S(O), SO2, C(O), or bond; Ra is H and C1-6 hydrocarbyl; ring B is (un)substituted mono-, bi-, tri-, or tetracyclic heterocyclic ring system containing heteroaryl and at least two ring N atoms; and pharmaceutically acceptable salts thereof. Example compound II was prepared via a multistep process with key step of coupling tert-Bu ((1-(5-chloro-4-cyano-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate with 2,3-dichlorophenylboronic acid followed by deprotection. Invention compounds were evaluated for their SHP2 inhibitory activity (data given). The experimental process involved the reaction of 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine(cas: 98138-75-1).Category: pyrazoles-derivatives
The Article related to shp2 inhibition treatment cancer, heteroaromatic preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics