On July 29, 2022, Perma Tenzin, Puno; Sun, Handong; Zhou, Yuanfei; Yan, Bingchao; Yang, Qian; Du, Xue; Hu, Kun published a patent.Related Products of 1014631-89-0 The title of the patent was Preparation of ent-kauranoid derivatives as antitumor drugs. And the patent contained the following:
The invention discloses a preparation of ent-kauranoid derivatives I [wherein R=(un)substituted C3-C8 alkyl and cycloalkyl, heterocyclic group containing N, O, S, substituted Ph, etc.] as antitumor drugs, which has the advantages of easy availability of raw materials, high yield and good anti-tumor effect. For example, (3aS,5aR,6S,7aR,10S,12aS,12bR,13R)-6-hydroxy-5,5-dimethyl-9-methylene-3,7,8-trioxododecahydro-1H,3H-7a,10-methanocyclohepta[6,7]indeno[1,7a-c]furan-13-yl butyrate was prepared by the following steps: oxidation of oridonin; selective reduction; diazotization; oxidation; rearrangement reaction; cyclization to obtain calyx lactone B; esterification. The title compound is used to prepare anti-tumor drugs, and tumors include cervical cancer, colon cancer, ovarian cancer, lung cancer, prostate cancer, breast cancer and liver cancer. The experimental process involved the reaction of 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid(cas: 1014631-89-0).Related Products of 1014631-89-0
The Article related to preparation ent kauranoid antitumor oxidation reduction diazotization cyclization esterification, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Related Products of 1014631-89-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics