On August 5, 2021, Wilson, Kevin J.; Schiller, Shawn E.R.; Negretti, Solymar published a patent.Related Products of 215610-30-3 The title of the patent was Carboxamide compounds for the treatment of BAF complex-related diseases and their preparation. And the patent contained the following:
The disclosure features compounds of formula I useful for the treatment of BAF complex-related disorders. Compounds of formula I wherein A is substituted oxetan-3-ylphenyl, (un)substituted bicyclic heterocyclic ring system; B is (un)substituted 6-membered heteroarylene and (un)substituted 9- to 10-membered bicyclic heteroarylene; L is a covalent bond, (un)substituted C1-3 alkylene, C2 alkynylene, (un)substituted C2 alkenylene, etc.; E is (un)substituted 3- to 10-membered cycloalkylene, (un)substituted 6- to 10-membered aryl, (un)substituted 5- to 10-membered heteroaryl, etc.; M is absent, (CR2R3)1-3; R1 is H and (un)substituted C1-6 alkyl; R2 and R3 are independently H, (un)substituted C1-6 alkyl and (un)substituted C1-6 heteroalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cross-coupling of tert-Bu N-[(4-bromo-2-pyridyl)methyl]carbamate with Me 3-ethynylbenzoate; the resulting Me 3-[2-[2-[(tert-butoxycarbonylamino)methyl]-4-pyridyl]ethynyl]benzoate underwent hydrolysis to give Me 3-[2-[2-(aminomethyl)-4-pyridyl]ethynyl]benzoate, which underwent N-acylation with (4R)-4-cyano-4-methyl-chromane-6-carboxylic acid to give compound II. The invention compounds were evaluated for BRM and BRG1 inhibitory activity (some data given). The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Related Products of 215610-30-3
The Article related to carboxamide preparation treatment baf complex disease, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Related Products of 215610-30-3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics