On December 31, 2012, Ablajan, Keyume; Wang, Liju published an article.Synthetic Route of 36640-53-6 The title of the article was Convenient synthesis and characterization of hydrazone derivatives of 3-(2-naphthyl)-1-phenyl-pyrazole-4-carbaldehyde. And the article contained the following:
In order to obtain novel hydrazone derivatives containing pyrazole and thiazole rings which possess certain biol. activity, a series of 1-(3-β-naphthyl-1-phenylpyrazole-4-methylene)-2-(4-arylthiazol-2-yl)hydrazones I(R = Ph, 4-Me-C6H4, 4-MeO-C6H4, 4-Cl-C6H4, 4-NO2-C6H4, 4-Br-C6H4, 2-naphthyl) were synthesized via two different methods including multi step reactions and one-pot synthetic route using 3-β-naphthyl-1-phenyl-pyrazole-4-carbaldehyde as a starting intermediate. The products were obtained in good yield under ultrasonic irradiation condition rather than heating. The structures of products were characterized by 1H NMR, MS and elemental anal. The preliminary bioassay showed that compounds I(R = 4-Me-C6H4, 4-Cl-C6H4) possess obvious protective effects on the PC12 cells injury induced by H2O2. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Synthetic Route of 36640-53-6
The Article related to naphthylphenylpyrazolemethyleneaiylthiazolylhydrazone preparation pc12 cell protection, naphthylphenylpyrazole carbaldehyde preparation hydrazinecarbothioamide arylcarbonylmethyl bromide cyclocondensation and other aspects.Synthetic Route of 36640-53-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics