Nicolaou, K. C.; Rhoades, Derek; Wang, Yanping; Totokotsopoulos, Sotirios; Bai, Ruoli; Hamel, Ernest published an article in 2015, the title of the article was Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues.Formula: C8H11BrN2O And the article contains the following content:
The design, synthesis, and biol. evaluation of a series of epothilone analogs with novel side chains equipped with an amino group are described. Their design facilitates potential conjugation to selective drug delivery systems such as antibodies. Their synthesis proceeded efficiently via Stille coupling of a readily available vinyl iodide and heterocyclic stannanes. Cytotoxicity studies and tubulin binding assays revealed two of these analogs, I (R = CF3, F), to be more potent than epothilones A-D and the anticancer agent ixabepilone, currently in clin. use. The experimental process involved the reaction of 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole(cas: 1187582-58-6).Formula: C8H11BrN2O
The Article related to epothilone b side chain analog preparation antitumor structure activity, tubulin binding epothilone b side chain analog, antibody-drug conjugates, anticancer agents, epothilones, organic synthesis, tubulin binding agents and other aspects.Formula: C8H11BrN2O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics