Rajashakar, V.; Saisree, K.; Sikender, M.; Naveen, S.; Madhava Reddy, B.; Harinadha Babu, V. published an article in 2016, the title of the article was Synthesis of pyrazolyl thiobarbituric acids and their cytotoxic and antimicrobial evaluation.HPLC of Formula: 36640-53-6 And the article contains the following content:
Synthesis, cytotoxic and anti-microbial screening of novel thiobarbituric acid incorporated pyrazole derivatives I [Ar = Ph, 4-H3CC6H4, 4-HOC6H4, 4-ClC6H4 and 2-naphthyl] were performed. Vilsmeier-Haack reaction of different Ph hydrazones afforded pyrazole-4-carbaldehydes in good yields. Knoevenagel condensation of compounds with thiobarbituric acid gave a series of 5-ylidene derivatives I in reasonable yields. The synthesized compounds were characterized with the help of IR, 1H-NMR and mass spectral data. The compounds were tested for cytotoxic activity against Vero, MCF-7 and HCT-116 cell lines. Among the tested compounds, compound I [Ar = 4-HOC6H4] was found to be most active mol. with the activity against both MCF-7 and HCT-116 cell lines with IC50 values of 14.0 μM and 18.12 μM. In anti-microbial screening, none of the compounds exhibited anti-bacterial activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).HPLC of Formula: 36640-53-6
The Article related to arylethylideneamino aniline preparation vilsmeir haack reaction, aryl phenylpyrazolyl carboxaldehyde preparation thiobarbituric acid knoevenagel condensation, phenyl arylpyrazolylmethylene thioxopyrimidine dione preparation antibacterial antitumor activity sar and other aspects.HPLC of Formula: 36640-53-6
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics