On September 30, 2021, Ameriks, Michael K.; Laforteza, Brian Ngo; Ravula, Suchitra; Schiffer, Jamie M.; Stenne, Brice M. published a patent.Electric Literature of 143803-93-4 The title of the patent was Preparation of fused and bridged compounds as monoacylglycerol lipase modulators. And the patent contained the following:
This invention relates to the title compounds I [R1a = alkyl; R1b = H; or R1a and R1b taken together form (CH2)2-3; R2 = (un)substituted Ph, pyridyl, bicyclic heteroaryl; R3 = 1H-alkyl-pyrazolyl, 1H-haloalkyl-pyrazolyl, 1H-pyridyl-pyrazolyl, etc.; with the proviso], and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, to pharmaceutical compositions containing them, to methods of making them, and to methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurol. disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions. E.g., a multi-step synthesis of (S)-II, starting from Et L-alaninate hydrochloride and Et 4-bromobutanoate, was described. Exemplified compounds I were tested for their in vitro activity of MGL (data given for representative compounds I). The experimental process involved the reaction of 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 143803-93-4).Electric Literature of 143803-93-4
The Article related to analgesics, antidepressants, antitumor agents, anxiety disorders (anxious depression), anxiolytics, asperger syndrome, bipolar disorder, depression (treatment-resistant), eye disease and other aspects.Electric Literature of 143803-93-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics