Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Reference of 37622-90-5.
Li, Yanni;Li, Yanping;Li, Yuan;Chen, Chunlin;Ying, Fengyuan;Dong, Ying;Liang, Deqiang research published 《 Metal-free cross-dehydrogenative C-N coupling of azoles with xanthenes and related activated arylmethylenes》, the research content is summarized as follows. A metal-free C(sp3)-H/N-H cross-coupling of azoles as acetamide, pyrazole, 1,2,4-triazole, etc. with xanthenes 9H-xanthene, thioxanthene, 2-chloro-thioxanthene, etc. and related activated arylmethylenes as (4-methoxyphenyl)methyl benzoate, diphenylmethane, isochromane, N-benzoyl-1,2,3,4-tetrahydroisoquinoline is presented. Both the use of azoles and the activation pattern of C(sp3)-H sources are essential for this transformation. In the presence of 2.0 equiv of benzoyl peroxide (BPO), methylenes bearing a heteroatom-bridged bisaryl group reacted with various azolic N-H sources to afford C-N bond forming products e.g., 1-(9H-xanthen-9-yl)-1H-benzo[d][1,2,3]triazole in usually excellent or quant. yields, and the diphenylmethane and methylenes coactivated by a Ph group and an adjacent heteroatom are less reactive. Mechanistic investigations suggest that a radical/radical cross-coupling pathway might be involved.
37622-90-5, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g/mol. The purity is usually 95%.
Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, Reference of 37622-90-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics