175137-46-9, These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound of example 33 (4.92 mmol) was reacted with 5-cyclopropyl-1H-pyrazol-3-amine(5.91 mmol) in presence of DMF (4.92 mmol), ethanol (148 mmol), sodium iodide (4.92 mmol)and triethylamine (24.62 mmol). The reaction mixture was stirred at a temperature of 100 C for 2 days. The DMF and excess triethylamine was evaporated followed by addition of water and ethyl acetate. The organic layer was separated and concentrated for purification using column chromatography (silica gel, 0.5 % methanol dichloromethane) to obtain the title compound.Yield: 70.1 %; ?H NMR (DMSO-d6, 300 MHz): oe 12.14 (s, 1H), 9.00 (s, 1H), 6.23(s, 1H), 2.59 (bs, 2H), 2.50 (d, 1=9.9Hz, 2H), 1.90 (m, 1H), 1.73 (bs, 4H), 0.93 (d, 1=6.6Hz, 2H), 0.69 (m, 2H); MS (ES+): mlz 418.3 (M+1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 175137-46-9.