In 2018,Wuji Huaxue Xuebao included an article by Li, Song; Gan, Xian-xue; Tang, Liang-fu. Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol. The article was titled 《Syntheses and catalytic properties of metal carbonyl derivatives with hydroxymethyl functionalized pyrazoles》. The information in the text is summarized as follows:
Reaction of tungsten or molybdenum carbonyl with 3(5)-hydroxymethyl-5(3)-methylpyrazole (L1), 4-hydroxymethylpyrazole (L2) and bis(3-hydroxymethyl-5-methylpyrazol-1-yl)methane (L3) yielded complexes LW(CO)5 (L = L1 or L2) and L3M(CO)4 (M = Mo or W), resp. These complexes have been fully characterized by NMR, IR and x-ray crystal structural analyses, indicating that they form 1D or 2D organometallic supramol. architectures through O-H···O, N-H···O and O-H···OC-M hydrogen bonding interactions, and these structures are significantly affected by the relative position of the hydroxymethyl group on the pyrazole ring. In addition, these complexes show moderate catalytic activity for the cyclotrimerization reaction of phenylacetylene. The experimental part of the paper was very detailed, including the reaction process of (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol)
(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of (3-methyl-1H-pyrazol-5-yl)methanol
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics