Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleIn 2017 ,《Stereoselective Photoredox-Catalyzed Chlorotrifluoromethylation of Alkynes: Synthesis of Tetrasubstituted Alkenes》 was published in Organic Letters. The article was written by Han, Hong Sik; Lee, Young Jin; Jung, Young-Sik; Han, Soo Bong. The article contains the following contents:
In the presence of fac-Ir(ppy)3 and Li2CO3 in acetone, trifluoromethanesulfonyl chloride added regioselectively and diastereoselectively to aryl alkynes such as 4-MeCONHC6H4CCMe under blue LED light to yield tetrasubstituted aryl trifluoromethyl alkenes such as I (R = Cl) in 34-85% yields and in all but one case as single diastereomers. I (R = Cl) underwent Suzuki coupling with aryl boronic acids or pinacolboronates to yield tetrasubstituted alkenes I (R = 4-EtOC6H4, 1-methyl-5-pyrazolyl, 3-furanyl, 2-benzothienyl) in 71-90% yields. The structure of a (tosylaminophenyl)chlorotrifluorobutene was determined by X-ray crystallog. The experimental part of the paper was very detailed, including the reaction process of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Recommanded Product: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics