《Synthesis and solid-state structure of thermally stable linear bi-pyrazoles》 was written by Maspero, Angelo; Cernuto, Giuseppe; Galli, Simona; Palmisano, Giovanni; Tollari, Stefano; Masciocchi, Norberto. Electric Literature of C9H7N3O2 And the article was included in Solid State Sciences on August 31 ,2013. The article conveys some information:
The long and rigid bi-pyrazolyl-based ligands 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone, , and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole, were isolated in pure form, with satisfying yields, as very insoluble polycrystalline materials. Their thermal behavior was studied by coupling thermal analyses and variable-temperature x-ray powder diffraction measurements. Their crystal structures were unraveled from powder diffraction data by a rather unconventional structure determination approach, without the a priori knowledge of the unit cell parameters. Inline with shorter analogs, successfully employed in the formation of porous MOFs with intriguing functional properties, 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole are promising to construct higher-porosity materials, potentially capable of hosting nano-sized guests.4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Electric Literature of C9H7N3O2) was used in this study.
4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Electric Literature of C9H7N3O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics