In 2013,Zhang, Yu-juan; Xing, Lei; Chen, Guo-liang published 《Synthesis of pinacol 1-methyl-1H-pyrazole-5-boronate》.Jingxi Huagong Zhongjianti published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:
Alkyl-pyrazole acid is an important intermediate for the synthesis of many biol. active compounds The target compound was prepared in overall yield of 27.4% starting from 1H-pyrazole via methylation with tri-Me phosphate, converting into boronic acids with tri-Me borate after reaction with Bu lithium, and condensation with pinacol. The process conditions were optimized for the synthesis and purification of intermediate 3. The structure of target compound was characterized by 1H NMR. In the experiment, the researchers used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Category: pyrazoles-derivatives)
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics