Application of 114474-26-9On November 30, 2013 ,《Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents》 appeared in Medicinal Chemistry Research. The author of the article were Xu, Shengjie; Li, Shenghui; Tang, Yonghe; Zhang, Jinchao; Wang, Shuxiang; Zhou, Chuanqi; Li, Xiaoliu. The article conveys some information:
A novel series of N-arylpyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2, 4-NO2), II, III and IV(R = H, OC8H17) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were established on the basis of elemental (C, H, and N) and spectral anal. (1H NMR, 13C NMR, HRMS, and FT-IR). All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines: carcinoma (Bel-7402), nasopharyngeal carcinoma (KB), immature granulocyte leukemia (HL-60), and gastrocarcinoma (BGC-823) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results showed that most of the obtained compounds exhibited promising cytotoxicity against tested carcinoma cell lines with low IC50 values. The bis-pyrazole derivative IV(R = OC8H17), bearing alkoxy group on the 5-position of Ph ring, was the most effective one. It is inhibition of cell growth of Bel-7402 cells was 1.5-fold higher than that found for cisplatin. And, also mono-pyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2) decorated with trifluoromethyl group on the Ph ring, displayed better cytotoxicity than that of cisplatin against Bel-7402 cell line. After reading the article, we found that the author used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Application of 114474-26-9)
4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Application of 114474-26-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics