Moriyama, Kei’s team published research in Journal of Medicinal Chemistry in 2008 | CAS: 15366-34-4

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.SDS of cas: 15366-34-4

SDS of cas: 15366-34-4In 2008 ,《Effects of Introduction of Hydrophobic Group on Ribavirin Base on Mutation Induction and Anti-RNA Viral Activity》 was published in Journal of Medicinal Chemistry. The article was written by Moriyama, Kei; Suzuki, Tetsuya; Negishi, Kazuo; Graci, Jason D.; Thompson, Corinne N.; Cameron, Craig E.; Watanabe, Masahiko. The article contains the following contents:

One of the possible mechanisms of antiviral action of ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, 1) is the accumulation of mutations in viral genomic RNA. The ambiguous incorporation of 5′-triphosphate of ribavirin (RTP, 8) by a viral RNA-dependent RNA polymerase (RdRp) is a key step of the mutation induction. The authors synthesized three ribavirin analogs that possess hydrophobic groups, 4-iodo-1-β-D-ribofuranosylpyrazole-3-carboxamide (I), 4-propynyl-1-β-D-ribofuranosylpyrazole-3-carboxamide (II), and 4-phenylethynyl-1-β-D-ribofuranosylpyrazole-3-carboxamide (III), and the corresponding triphosphates (IV, V, and VI, resp.). Steady-state kinetics anal. of the incorporation of these triphosphate analogs by a poliovirus RdRp, 3Dpol, revealed that while the incorporation efficiency of IV was comparable to RTP, V and VI showed lower efficiency than RTP. Antipolioviral activity of I and II was much more moderate than ribavirin, and III showed no antipolioviral activity. Effects of substituting groups on the incorporation efficiency by 3Dpol and a strategy for a rational design of more active ribavirin analogs are discussed. In the experimental materials used by the author, we found Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4SDS of cas: 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.SDS of cas: 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics