Sidhom, Ameni; Soule, Jean-Francois; Doucet, Henri; Allouche, Fatma published the artcile< Reactivity of 5-aminopyrazoles bearing a cyclopropyl group at C3-position in palladium-catalyzed direct C4-arylation>, Reference of 118430-74-3, the main research area is cyclopropyl methyl pyrazolamine bromobenzene palladium catalyst chemoselective regioselective arylation; phenyl cyclopropyl methyl pyrazolamine green preparation.
Pyrazole derivatives bearing a cyclopropyl group at C3-position and an amino substituent at C5 were successfully employed in palladium-catalyzed direct arylations. These couplings were performed using air-stable PdCl(C3H5)(dppb) catalyst associated to KOAc as inexpensive base and afforded regioselectively the C4-arylated pyrazoles without decomposition of the cyclopropyl unit and formation of amination products. A wide variety of functional groups on the aryl bromide including electron-withdrawing and electron-donating ones such as nitrile, nitro, propionyl, ester, trifluoromethyl, chloro, fluoro or methoxy was tolerated. Moreover, from 5-aminopyrazoles bearing N-2′-bromoaryl or 2′-bromobenzenesulfonamide substituent on the amino group, intramol. Pd-catalyzed direct arylations allowed the formation of tricyclic compounds by formation of 5- or 6-membered rings.
Catalysis Communications published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Reference of 118430-74-3.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics