Caliskan, Burcu’s team published research in Medicinal Chemistry Research in 2013 | CAS: 192701-73-8

Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate

Caliskan, Burcu; Yilmaz, Akin; Evren, Ilker; Menevse, Sevda; Uludag, Orhan; Banoglu, Erden published an article on February 28 ,2013. The article was titled 《Synthesis and evaluation of analgesic, anti-inflammatory, and anticancer activities of new pyrazole-3(5)-carboxylic acid derivatives》, and you may find the article in Medicinal Chemistry Research.Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate The information in the text is summarized as follows:

1-Benzyl-5(3)-p-tolyl-1H-pyrazole-3(5)-carboxylic acid derivatives were prepared and characterized by IR, 1H NMR, and mass spectroscopy. Compounds were evaluated for their in vivo analgesic and anti-inflammatory activity using the p-benzoquinone-induced writhing test and the carrageenan-induced paw edema model, resp. Out of 14 compounds tested, exhibited potent analgesic and/or anti-inflammatory activity as compared to reference drugs aspirin and indomethacin. Anticancer activity of these compounds was assessed against five cancer cell lines with the MTT assay (HL-60, human promyelocytic leukemia cells; HeLa, human cervical cancer cells; Raji, human B lymphocyte cell line; MCF7, human breast adenocarcinoma cell line; MDA-MB-231, estrogen-independent human breast cancer cell line). Three compounds with high anti-inflammatory activity, and also two compounds with mild anti-inflammatory activity exhibited promising anticancer activity against some selected cell lines. In addition to this study using Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate, there are many other studies that have used Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate) was used in this study.

Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate(cas: 192701-73-8) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Name: Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics