O’Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. The article was titled 《Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles》, and you may find the article in Journal of Organic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:
The first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions is reported. Importantly, this method does not require the C4 and C5 positions of the pyrazole to be functionalized to observe regioselectivity. Using this method, authors completed the synthesis of a recently reported JAK 1/2 inhibitor. Authors’ synthesis produces the desired product in 4 steps from com. available starting materials. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics